See full prescribing information for SODIUM THIOSULFATE INJECTION. In pH testing of bleach substances, sodium thiosulfate neutralizes the color-removing effects of bleach and allows one to test the pH of bleach solutions with liquid indicators. [9][2] Thiosulfate forms strong soluble complexes with gold(I) ions, [Au(S2O3)2]3−. In deciding to use a medicine, the risks of taking the medicine must be … Mechanism of action. It is used to dechlorinate tap water including lowering chlorine levels for use in aquariums, swimming pools, and spas (e.g., following superchlorination) and within water treatment plants to treat settled backwash water prior to release into rivers. When the diagnosis... 2. 0000005792 00000 n Although acute acrylonitrile (ACN) toxicity is very profound, the mechanism of its toxicity and immediate lethality is unclear. sodium thiosulfate uses offered at Alibaba.com meet and exceed the set quality and safety standards as per the current industry regulations. 0000007375 00000 n Find patient medical information for sodium thiosulfate intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 0000149474 00000 n EC Number 231-867-5. Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. It contains a thiosulfate(2-). Sodium Thiosulfate Injection, USP Initial U.S. Approval: 1992 INDICATIONS … The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. Medical uses. You said in a post on earthclinic that one remedy to counteract Herxheimers die-off is 1 teaspoon of Sodium Thiosulphate 4 to 10 times a day. Sodium thiosulfate is used to treat fungal infections like ringworm. The products being sensitive should always be purchased from verified sellers to … On an industrial scale, sodium thiosulfate is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture. 0000004134 00000 n The normality of a solution is equal to the number of equivalents multiplied by the molarity. Sodium thiosulfate has no known interactions with other drugs. 0000204225 00000 n 0000050090 00000 n 0000000016 00000 n Antioxidant. Sodium thiosulfate is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. This reaction is known as a "clock reaction", because when the sulfur reaches a certain concentration, the solution turns from colorless to a pale yellow. Silver halides, e.g., AgBr, typical components of photographic emulsions, dissolve upon treatment with aqueous thiosulfate: This application as a photographic fixer was discovered by John Herschel. 124 0 obj <>stream Sodium thiosulfate, or sodium thiosulphate, is a colorless, water-soluble salt. 0000076785 00000 n It is also used as adjunct agent for patients taking cisplatin chemotherapy. Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). 0000006763 00000 n 0000014338 00000 n Sodium thiosulfate can be used for treatment of acute cyanide poisoning in combination with sodium nitrite. Sodium thiosulfate (Intravenous) Uses for sodium thiosulfate. It is also used in some vital tests for kidney patients to glean information without doing harm. 0000225002 00000 n Until now, no recurrence of … Sodium thiosulfate is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. Other articles where Sodium thiosulfate is discussed: sodium: Principal compounds: Sodium thiosulfate (sodium hyposulfite), Na2S2O3, is used by photographers to fix developed negatives and prints; it acts by dissolving the part of the silver salts coated onto film which remain unchanged by exposure to light. Stars This entity has been manually annotated by the ChEBI Team. 5H 2 O, an efflorescent, monoclinic crystalline substance also called sodium hyposulfite or "hypo." SODIUM THIOSULFATE. Medical uses of Sodium thiosulfate Patrick L. McGeer*, Edith G. McGeer and Moonhee Lee Kinsmen Laboratory of Neurological Research, University of British Columbia, VancouverBC V6T 1Z3, Canada Background Sodium thiosulfate (Na 2 S 2 O 3, STS) is an industrial compound which has a long history of medical use. It is available in a liquid solution or in a dry, pellet form. Sodium thiosulfate: At the beginning of the development of the chemical, the formula of this additive was considered Na 2 S 2 O 4 and was named sodium hypo-sulfate.The short name is called Hypo.Later its formula Na 2 S 2 O 3 was established. 0000010192 00000 n Sodium thiosulfate is generally used in conjunction with sodium nitrite in the treatment of cyanide poisoning. 0000263289 00000 n Uses of Sodium Thiosulfate: It is used to treat cyanide poisoning. Sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine. The solid is an efflorescent (loses water readily) crystalline substance that dissolves well in water. Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer... Before using sodium thiosulfate. 0000011723 00000 n Sodium thiosulfate is readily soluble in water and is a mild reducing agent. Sodium thiosulfate is readily soluble in water and is a mild reducing agent. The calcium-chelating properties of sodium thiosulfate make it a useful agent for treating disorders involving excess calcium. 0000142747 00000 n Molecular Weight 158.11 . 12.5 g, to be given over 10 minutes, dose may be repeated in severe cyanide poisoning. 0000006039 00000 n You can use thiosulfate when measuring the concentration of one oxidant, hypochlorite, in a container of bleach. For Child. Two polymorphs are known of the pentahydrate. 0000018319 00000 n [2] The reduction reaction is analogous to the iodine reduction reaction. The reduction reaction is analogous to the iodine reduction reaction, the t… When the protonation is conducted in diethyl ether at −78 °C, H2S2O3 (thiosulfuric acid) can be obtained. 32 93 More recently, several reports have suggested that STS may be of interest in the treatment of ectopic calcifications due to metabolic or inflammatory diseases (9, 10). 0000003271 00000 n 0000149988 00000 n of water. [13] The alkylthiosulfates are susceptible to hydrolysis, affording the thiol. NACRES NA.21 for bubble baths and hair bleaches, or as a fine chemical, e.g. For Adult. Sodium Thiosulfate Vial Common Brand(S): Generic Name(S): sodium thiosulfate View Free Coupon . Sodium thiosulfate is indicated for sequential use with hydroxocobalamin or sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. Total parathyroidectomy was carried out 6 months after the STS therapy, which successfully solved hyperparathyroidism and the high calcium-phosphorus profiles. Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Sodium thiosulfate might act by preventing calcium from displacing gadolinium from its chelate (transmetallation) [110]. Sodium thiosulfate (STS) was used for treatment in this case. It may be in the form of a clear liquid, a white powder, or a white tablet in the bottom of the bottle. 0000203829 00000 n Sodium thiosulfate is to be administered only by or under the immediate supervision of your doctor. Sodium thiosulfate is that antidote. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. Posted by L (India) on 08/23/2012. Initial protonation occurs at sulfur. Hello Ted, I would be most grateful if you could please advise on 2 simple questions below: 1. Animal studies show risk and human studies are not available or neither animal nor human studies were done. 0000005533 00000 n 0000003296 00000 n 0000224016 00000 n It is an important antidote used for treating cyanide poisoning. Cancer Resources. of water. It has a role as an antidote to cyanide poisoning, a nephroprotective agent and an antifungal drug. Sodium thiosulfate is an inorganic sodium salt composed of 2:1 mixture of sodium and thiosulfate ions. It has a role as an antidote to cyanide poisoning, a nephroprotective agent and an antifungal drug. 0000156252 00000 n 0000010321 00000 n Due to its acronym hypo becoming more popular, its common name is still hypo today. Sodium Thisulphate powder is used to de-chlorinate ballast waters prior to discharge to the environment. Indications of the sodium thiosulfate It is used as an antidote in the case of salt poisoning of elements such as As with I, Hg and Br, and also Pb, and in addition, with intoxication with hydrocyanic acid or cyanides. No matter what kind of sodium thiosulfate uses you are seeking, whether for a manufacturing process, cleaning process, or any other reactions, you will find many options to suit your needs. It is a somewhat strong acid with pKas of 0.6 and 1.7 for the first and second dissociations, respectively. 5H 2 O, an efflorescent, monoclinic crystalline substance also called sodium hyposulfite or "hypo." [10], In the laboratory, this salt can be prepared by heating an aqueous solution of sodium sulfite with sulfur or by boiling aqueous sodium hydroxide and sulfur according to this equation:[11]. 0000015024 00000 n carbonaceous or Carlin-type ores) can be leached by thiosulfate. Mix 5 grams (or 1 teaspoon) of Sodium Thiolsulphate with 3 oz water and drink. Often, sodium thiosulfate is prescribed for psoriasis, namely, for exacerbation of this disease. Sodium thiosulfate, used for IV injections, receives positive feedback - it is considered extremely effective in intoxication, as well as when eliminating alcohol dependence. Use sodium thiosulfate with caution during pregnancy if benefits outweigh risks. It has been indicated as antidote for cyanide poisoning. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first. Because it dissolves silver salts, its major use is in photography for developing film. Sodium thiosulfate. Cyanide has a high affinity for ferric ions, and reacts readily with the ferric ion of mitochondrial cytochrome oxidase. More recently, doctors began to use it to clean the body. No other clinical or biochemical compli­cations were observed. The S-S distance indicates a single bond, implying that the terminal sulfur holds a significant negative charge and the S-O interactions have more double-bond character. 0 Total parathyroidectomy was carried out 6 months after the STS therapy, which successfully solved hyperparathyroidism and the high calcium-phosphorus profiles. It is given by injection into a vein.. 0000204341 00000 n Some problems with this alternative process include the high consumption of thiosulfate, and the lack of a suitable recovery technique, since [Au(S2O3)2]3− does not adsorb to activated carbon, which is the standard technique used in gold cyanidation to separate the gold complex from the ore slurry. From . Product information Specification Documents Related products Product information. 0000008714 00000 n 0000540265 00000 n The sodium thiosulfate is also used as a photographic fixer, known as "Hypo" to prevent the chemicals of photgraphs from further getting dark and fix the pictures, much like a preservative, from preventing the pictures to be developed from further chemical oxidation. 0000003076 00000 n In five patients with systemic fibrosis extracorporeal photopheresis produced mild improvements in three cases in skin tightening, range of motion, and/or functional capacity after a mean number of 34 treatment sessions over a mean of 8.5 months [ 111 ]. Sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine. It is also used with another medicine in the emergency treatment of cyanide poisoning. Also called sodium hyposulphite and its formula is Na 2 S2O 3 .. Sodium Thiosulfate Injection is a cyanide antidote which contains one 50 mL glass vial containing a 25% solution of Sodium Thiosulfate Injection. Poisoning with cyanides. Sodium thiosulfate (STS) (Na 2 S 2 O 3) is used to prevent and treat cyanide poisoning . Medical uses of Sodium thiosulfate Patrick L. McGeer*, Edith G. McGeer and Moonhee Lee Kinsmen Laboratory of Neurological Research, University of British Columbia, VancouverBC V6T 1Z3, Canada Background Sodium thiosulfate (Na 2 S 2 O 3, STS) is an industrial compound which has a long history of medical use. Sodium sulfate (also known as sodium sulphate or sulfate of soda) is the inorganic compound with formula Na 2 SO 4 as well as several related hydrates.All forms are white solids that are highly soluble in water. 0000018388 00000 n It is used for both film and photographic paper processing; the sodium thiosulfate is known as a photographic fixer, and is often referred to as 'hypo', from the original chemical name, hyposulphite of soda. 0000009487 00000 n %PDF-1.7 %���� 0000002962 00000 n Applied in a widely useful, thiosulfate-assisted, synthesis of a variety of diamine-CuCN complexes. 0000142472 00000 n It is a dry acid in crystal, granular, or powder form that is used as a pH adjuster, fungicide, herbicide, or microbiocide (a product that kills microbes) in a variety of industries, such as household cleaning and swimming pool maintenance. 0000005568 00000 n 0000005681 00000 n This reaction is illustrated by one synthesis of thioglycolic acid: InChI=1S/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2, InChI=1/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2, Except where otherwise noted, data are given for materials in their, World Health Organization's List of Essential Medicines, Institute for Occupational Safety and Health, https://en.wikipedia.org/w/index.php?title=Sodium_thiosulfate&oldid=1004442724, World Health Organization essential medicines, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 48.3 °C (118.9 °F; 321.4 K) (pentahydrate), 100 °C (212 °F; 373 K) (pentahydrate, - 5H, This page was last edited on 2 February 2021, at 16:39. 0000142586 00000 n It contains a thiosulfate(2-). 0000204160 00000 n as denaturing agent in gel electrophoresis. In addition, the drug is used to remove scabies, SLE, arthritis with neuralgia, as … The anhydrous salt exists in several polymorphs. 0000199599 00000 n 0000013363 00000 n 0000050355 00000 n 0000156441 00000 n Medical Uses and Benefits of Sodium Thiosulfate. 0000178643 00000 n PubChem Substance ID 329752199. 3. Sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine. The unique ability of a substance lies in its ability to find, bind and excrete poisons and toxins that normally accumulate in the tissues of the human body. This particular use can be set up to measure the oxygen content of water through a long series of reactions in the Winkler test for dissolved oxygen. 0000156788 00000 n It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Sodium thiosulfate (Na 2 S2O3) is a satisfactory dechlorinating agent that neutralizes any residual halogen and prevents continuation of bactericidal action during sample transit. sodium thiosulfate pentahydrate: ChEBI ID CHEBI:32150: Definition A hydrate consisting of sodium thiosulfate with 5 mol eq. Pure sodium dodecyl sulphate is used mainly in dentifrice products, in hair shampoos, and in emulsion polymerization . Both tumoral calcinosis and calcific nephrolithiasis have been successfully treated with the salt. Sodium nitrite reacts with haemoglobin to form methaemoglobin, and cyanide preferentially binds to methaemoglobin, restoring cytochrome oxidase activity. Consult your doctor before breastfeeding. 0000540573 00000 n 0000007648 00000 n The complete reaction is: Similarly, sodium thiosulfate reacts with bromine, removing the free bromine from solution. 0000178896 00000 n The sodium thiosulfate or sodium hyposulfite (Na 2 S 2 OR 3) It is an important inorganic salt with various medical uses. Sodium Thiosulfate is used internally to remove chlorine, cyanide, and heavy metals. 0000179294 00000 n Stars This entity has been manually annotated by the ChEBI Team. 0000003147 00000 n Consult the National Poisons Information Service. Supplier Information [12] It can, when heated with a sample containing aluminium cations, produce a white precipitate: Alkylation of sodium thiosulfate gives S-alkylthiosulfates, which are called Bunte salts. 0000215189 00000 n Show all parts of this monograph; Indications and dose; Exceptions to legal category; Medicinal forms; Indications and dose. The people who use the solution with psoriasis therapy respond positively about the medicine, for the elimination of gynecological diseases and allergic pathologies. Sodium thiocyanate is a classical antidote to cyanide poisoning, For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases.