Guillain-Barré syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes. NOTE: A retrospective diagnosis is the practice of identifying a condition in a historical figure using modern knowledge, methods and medical classifications. Cerebral manifestations in the antiphospholipid (Hughes) syndrome. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. 193(2):249-54. . The syndrome is associated with risk of inappropriate blood clot formation, so it is considered an excessive clotting disorder (thrombophilia).. Antibodies normally defend the body against infections. 2 This occurs when an extra part or a whole extra chromosome 21 is present, but it is attached or “trans-located” to a different chromosome rather than being a separate chromosome 21. Clinical performance of an in-line, ex vivo point-of-care monitor: a multicenter study. Two-thirds of patients have a history of gastroenteritis or influenza-like illness weeks before onset of neurological symptoms. Lung. Epub 2014 Aug 7. Review. A large number of infections have been linked, including … Antiphospholipid syndrome (APS) is caused by the body's immune system producing abnormal antibodies called antiphospholipid antibodies. To aid diagnosis, several tests have been developed to recreate the pain by actively contracting or passively stretching the piriformis muscle and compressing the sciatic nerve. 2014 Nov;48(11):1479-83. doi: 10.1177/1060028014546361. Billman GF, Hughes AB, Dudell GG, et al. Guillain-Barré syndrome (GBS) is a disorder causing demyelination and axonal degeneration resulting in acute, ascending and progressive neuropathy, characterised by weakness, paraesthesiae and hyporeflexia.. About 75% of patients have a history of preceding infection, usually of the respiratory and gastrointestinal tract. Am J Med Genet A. 2002 Nov. 48(11):2030-43. 2015 Apr. Sun H, Zhou Y, Xiong H, et al. 2014;164A:48-53. The list below includes famous people for whom there is a lot of speculation that they have or had Aspergers Syndrome, but who may not have (or have had) Aspergers at all. Antiphospholipid syndrome (APS) is an autoimmune disorder, meaning that the body's immune system makes proteins known as antibodies that mistakenly attack its own cells or tissues. Rationale: The patient is presenting with fatigue and weight loss which may be indicative of diabetes mellitus type 2, and his blood glucose is abnormally high. This increases the risk of blood clots developing in the blood vessels, which can lead to serious health problems, such as: deep vein thrombosis (DVT) Prognosis of very preterm infants with severe respiratory distress syndrome receiving mechanical ventilation. Crowl A, Schullo-Feulner A, Moon JY. Peripheral neuropathy, a common neurologic problem encountered by family physicians, can be classified clinically by the anatomic pattern of presenting symptoms and, … Sanna G, D’Cruz D, Cuadrado MJ. Ann Pharmacother. Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. The most common treatable causes include diabetes mellitus, hypothyroidism, and nutritional deficiencies. ... Hughes SS, Welsh HI, Safina NP, et al. PubMed PMID: 25104566. Clin Chem. Antiphospholipid syndrome (APS), sometimes known as Hughes syndrome, is a disorder of the immune system that causes an increased risk of blood clots. Family history and clefting as major criteria for CHARGE syndrome. With poliomyelitis under control in developed countries, GBS is now the most important cause of acute flaccid paralysis. Piriformis syndrome (PS) is a painful musculoskeletal condition, characterized by a combination of symptoms including buttock or hip pain. Warfarin monitoring in antiphospholipid syndrome and lupus anticoagulant. Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Piriformis syndrome is a complex condition that is often not considered in the differential diagnosis of chronic hip and low back pain. Differential Diagnosis I. Diabetes mellitus type 2 is an ailment involving hyperglycemia and insulin resistance. People with this condition are genetically male, with one X chromosome and one Y chromosome in each cell. Peripheral neuropathy has a variety of systemic, metabolic, and toxic causes. This means people with APS are at greater risk of developing conditions such as: deep vein thrombosis (DVT), a blood clot that usually develops in the leg Guillain-Barre syndrome is an acute inflammatory polyneuropathy that is classified according to symptoms and divided into axonal and demyelinating forms. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. Translocation Down syndrome: This type accounts for a small percentage of people with Down syndrome (about 3%). The diagnosis of CHARGE syndrome should be made by a medical geneticist based on the presence of at least one major criterion and several minor and/or occasional criteria of CHARGE syndrome (see below).